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You'll need to run what's being referred to as anti-spyware software…There are a lot of options out there. Ones that I've used and have had good luck with are PestPatrol (now CA) and Spybot. If you're on a network with more than 10-15 computers, you'd likely do best with a solution that can be centrally managed so look for that.
Dig Deeper on Malware, virus, Trojan and spyware protection and removal
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