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The protection against this critter is the same as for any other -- run current antivirus software on all your machines. Klez has been known of since January 2002, so most any up-to-date scanner will find it.
For more information on this topic, visit these other SearchSecurity resources:
News & Analysis: Rise and shine for Klez-E
Best Web Links: Malware
Dig Deeper on Malware, Viruses, Trojans and Spyware
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