I'm going to assume that you're using a protocol that has a single arbitrary port for each connection negotiated between the client and the server. That's the case for a number of backup systems. If so, you may be able to configure and narrow down the port range to just high-numbered ones, those unused by other services. Once you limit the number of ports, be sure to also tightly control and reduce the IP range of systems that may connect...
to the server.
It's important to remember that security and convenience often have an inverse relationship. The true art of security is balancing the two and reaching compromises that effectively secure an organization's data while still allowing the company to meet its business objectives.
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