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Let's not throw out the baby with the bath water. Yes, antivirus tools are not perfect, but, they are a good element of a baseline security strategy. Some stuff will always squeak through, but the vendors are constantly improving as well. In the future, as we get more anomaly-based detection augmenting our signature and behavior-based detection, these products will help even more.
So, don't ditch your antivirus and antispam products. Keep them patched and up-to-date, and keep barking at your vendors to make sure they improve. It'll stop the majority of the stuff we face, but not everything. That's why you need to have a supporting strategy of a solid incident response team.
For more info on this topic, please visit these SearchSecurity.com resources:
Virus Prevention Tip: Keys to an effective virus incident-response team
Webcast: Advanced intrusion defense
Security Tool Shed: Target-based IDS muffles the noise to take aim on the alerts that count
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