Antimalware and antivirus programs can detect a large number of different types of malicious files and activity. Traditional antimalware software detects malware files based on antimalware definitions -- these are essentially signatures -- to identify malicious or infected files and then quarantine them. And the fact that malware includes database files will make it easily detectable by antimalware software. Many antimalware programs are now also using behavioral mechanisms to augment the signature-based detections.
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