Trouble getting rid of Klen.z virus

We have network of nearly 100 computers with Trend Micro antivirus enterprise suite running on our servers and...

client computers. The Klen.z worm is attacking all the computers despite loading the latest pattern files on all the servers and computers. (We are using Win2000 servers and Windows 98 client.) What can we do to solve this problem?

At this point, I suspect that you still have at least one infected machine on your network. All it takes is one to re-infect the others.

You need to systematically isolate each machine, doing a complete scan using at least two antivirus scanners and then re-connect it to the network, but without sharing any folders or using password protected folders.

Only once you have completely cleaned every machine will you be able to re-activate sharing.